| Expression pattern: |
UP |
| Associated gene: |
PTPN9 |
| Associated microRNA: |
miR-197-3p |
| Biological function: |
promotes tumorigenesis, proliferation, migration and invasion; promotes chemoresistance |
| Molecular mechanism: |
circMMD_007 negatively regulates miR-197-3p and thereby increases PTPN9 expression (ceRNA-like axis) to promote oncogenic phenotypes |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circMMD_007 expression was higher in advanced stages and associated with lymph node metastasis and distant metastasis status |
| Description: |
circMMD_007 is up-regulated in lung adenocarcinoma and its higher level associates with more advanced clinical stages/metastasis. Functionally, circMMD_007 promotes tumor cell growth, migration/invasion, and increases chemotherapy drug survival, partly by sponging miR-197-3p to relieve repression of PTPN9 (circMMD_007/miR-197-3p/PTPN9 axis). |
| Confidence score: |
0.8119 |