| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential circulating biomarker for AIS diagnosis and prediction of stroke outcomes; expression levels were positively correlated with cerebral infarct volume. |
| Molecular mechanism: |
Not experimentally defined; possible downstream mechanisms were assessed by bioinformatics analysis. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
The combination of three circRNAs had diagnostic value for AIS with an AUC of 0.875, specificity of 91%, and sensitivity of 71.5%; the combination of changing rates within the first 7 days had outcome prediction value with an AUC of 0.960. |
| Description: |
circFUNDC1 was significantly elevated in plasma from AIS patients compared with healthy controls. Together with circPDS5B and circCDC14A, it showed potential utility as a circulating biomarker for AIS diagnosis and prediction of stroke outcome, and circRNA levels were positively correlated with infarct volume. |
| Confidence score: |
0.5534 |