| Expression pattern: |
DN |
| Associated gene: |
FBXL2 |
| Associated microRNA: |
miR-346 |
| Biological function: |
Inhibits gastric cancer cell proliferation, migration and invasion (tumor suppressor-like activity). |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-346 and regulates FBXL2 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circSMARCA5 is down-regulated in gastric cancer tissues and cell lines. Its overexpression suppresses gastric cancer cell proliferation, migration, and invasion by sponging miR-346 and relieving miR-346-mediated repression of FBXL2 (miR-346/FBXL2 axis). |
| Confidence score: |
0.6479 |