| Expression pattern: |
DN |
| Associated gene: |
SMYD4, Bcl-2, cleaved Caspase-3, Bax, AFP, E-Cadherin, N-Cadherin, Vimentin |
| Associated microRNA: |
miR-584-5p |
| Biological function: |
Inhibits proliferation, migration and invasion and promotes apoptosis of hepatocellular carcinoma cells; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) targeting miR-584-5p, thereby regulating metastasis- and apoptosis-related genes/proteins (e.g., EMT markers; Bcl-2/Bax/cleaved Caspase-3) and AFP in vivo. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); metastasis (inhibits); EMT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Spearman correlation analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
circSMYD4 expression was negatively correlated with large tumor, high edmondson-steiner grading and TNM tumor stage; proposed as a potential biomarker for the diagnosis of HCC in previous reviews. |
| Description: |
circSMYD4 (hsa_circ_0004018), derived from SMYD4, is down-regulated in HCC tissues/cells and predominantly localized in the cytoplasm. Functionally, circSMYD4 acts as a tumor suppressor by inhibiting proliferation, migration/invasion and EMT while promoting apoptosis and reducing xenograft tumor growth. Mechanistically, it sponges miR-584-5p, and miR-584-5p overexpression partially rescues circSMYD4-mediated effects. |
| Confidence score: |
0.8596 |