| Expression pattern: |
DN |
| Associated gene: |
IL10RA, AKR1B10 |
| Associated microRNA: |
miR-1208 |
| Biological function: |
potential tumor suppressive role in CRC |
| Molecular mechanism: |
ceRNA (miRNA sponge) mechanism: circ_0000977 sponges miR-1208, potentially affecting IL10RA and AKR1B10 |
| Biological pathway or process: |
ceRNA regulation (inhibits); apoptosis (other); proliferation (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis |
| Clinical significance: |
suggested potential prognostic and therapeutic biomarker (not validated) |
| Description: |
circ_0000977 is predicted to be down-regulated in CRC and proposed to act as a tumor-suppressive circRNA. Bioinformatic analyses suggest it may sponge miR-1208, thereby potentially affecting tumor-suppressor genes such as IL10RA and AKR1B10 via a ceRNA mechanism. |
| Confidence score: |
0.1768 |