circRNA basic information
circBase ID: hsa_circ_0001917
Name: hsa_circ_CASK
Synonym: -
Host Gene: CASK
Genomic location(hg19): chrX:41519691-41530783:-
Genomic location(hg38): chrX:41660438-41671530:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; normal thyroid tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RIMS2
Associated microRNA: hsa-miR-139-5p
Biological function: May promote PTC via upregulation of RIMS2.
Molecular mechanism: ceRNA mechanism (sponging hsa-miR-139-5p) to upregulate RIMS2.
Biological pathway or process:

ceRNA regulation (promotes)
Detected method:
M
Validation methods:

Microarray; RNA-seq; Bioinformatics Analysis; Survival Analysis
Clinical significance:

-
Description:

hsa_circ_0001917 is upregulated in PTC and included in the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-139-5p and increase RIMS2 expression, potentially promoting PTC progression.
Confidence score:

0.4032
Other information
Title:

Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.

Journal: Frontiers in cell and developmental biology
Published: 2020
PubMed ID: 33553144
Study type:

bioinformatics study
Data availability: GSE93522; TCGA-THCA
Code availability: -