circRNA basic information
circBase ID: hsa_circ_0001190
Name: hsa_circ_DYRK1A
Synonym: circDYRK1A
Host Gene: DYRK1A
Genomic location(hg19): chr21:38792600-38794168:+
Genomic location(hg38): chr21:37420298-37421866:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; para-cancerous tissues
Cell lines:

HGC-27; AGS; MGC-803; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TP53
Associated microRNA: hsa-miR-485-5p, miR-93-5p
Biological function: inhibits proliferation; inhibits invasion; inhibits migration
Molecular mechanism: ceRNA mechanism (predicted), potentially sponging miR-93-5p to regulate TP53
Biological pathway or process:

proliferation (inhibits); invasion (inhibits); migration (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Wound Healing Assay
Clinical significance:

downregulation of circDYRK1A was correlated with tumor invasion and more advanced T stage in GC patients
Description:

circDYRK1A (hsa_circ_0001190) is down-regulated in gastric cancer tissues and GC cell lines. Overexpression of circDYRK1A inhibits proliferation, invasion, and migration of GC cells in vitro, and it is proposed to act via a circDYRK1A-miRNA-TP53 ceRNA axis.
Confidence score:

0.6046
Other information
Title:

circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations.

Journal: Scientific reports
Published: 2023
PubMed ID: 37217530
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -