| Expression pattern: |
UP |
| Associated gene: |
SOX4 |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
Promotes multiplication/proliferation, migration and invasion; inhibits apoptosis of cervical cancer cells. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-149-5p to upregulate SOX4 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Clinical Sample Validation |
| Clinical significance: |
High expression of circ_0011385 was associated with higher FIGO stage; suggested as an unfavorable prognostic biomarker and potential therapy target. |
| Description: |
circ_0011385 is up-regulated in cervical cancer tissues/cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation/migration/invasion) and inhibits apoptosis by sponging miR-149-5p, thereby increasing SOX4 expression (circ_0011385/miR-149-5p/SOX4 ceRNA axis). |
| Confidence score: |
0.7884 |