circRNA basic information
circBase ID: hsa_circ_0103398
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tumors; paired matched normal tissues; tumor and adjacent normal tissues; adjacent non-tumor mucosal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential prognostic biomarker for gastric cancer; high expression correlated with late TNM stage and unfavorable survival time.
Molecular mechanism: Concrete molecular mechanism was not clarified by biological experiments; functional enrichment suggested possible involvement of cancer-related pathways and immune processes.
Biological pathway or process:

p53 signaling (other); TGF-beta/SMAD (other); immune regulation (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High expression was closely related to unfavorable survival time; hsa_circ_0103398 was significantly correlated with prognosis.
Description:

hsa_circ_0103398 was identified as one component of a 5-circRNA prognostic signature in gastric cancer. It was experimentally validated by real-time PCR as upregulated in GC tissues, associated with late TNM stage, and high expression predicted unfavorable survival.
Confidence score:

0.5534
Other information
Title:

Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Published: 2020
PubMed ID: 31672718
Study type:

combined bioinformatics, clinical and biological validation study
Data availability: GSE79973; GSE62254; GSE15459
Code availability: -