circRNA basic information
circBase ID: hsa_circ_0007618
Name: hsa_circ_DOCK5
Synonym: -
Host Gene: DOCK5
Genomic location(hg19): chr8:25265498-25266456:+
Genomic location(hg38): chr8:25407982-25408940:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissue samples; serum
Cell lines:

PC9; H460; A549; H1299; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PIK3CA, NRAS
Associated microRNA: miR-627-3p, miR-597-3p, miR-676-5p, miR-224-3p, miR-26b-3p, miR-671-3p, miR-541-3p, miR-92a-1-5p, miR-514a-5p, miR-302a-5p
Biological function: unknown
Molecular mechanism: May bind miRNAs to regulate downstream genes in a circRNA-miRNA-mRNA (ceRNA) network.
Biological pathway or process:

ceRNA regulation (other); PI3K/AKT (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; divergent primers PCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

High levels of circ_0007618 are associated with poor OS in LUAD patients; ROC AUC in tissue 0.916 and in serum 0.838.
Description:

circ_0007618 is up-regulated in LUAD tissues, serum, and lung cancer cell lines, is mainly localized in the cytoplasm, and is proposed to act within a predicted ceRNA network by binding multiple miRNAs and regulating hub genes such as PIK3CA and NRAS. High circ_0007618 expression correlates with clinicopathological features and predicts poor overall survival, supporting its potential as a diagnostic/prognostic biomarker.
Confidence score:

0.7329
Other information
Title:

Circular RNA-microRNA-mRNA network identified circ_0007618 and circ_0029426 as new valuable biomarkers for lung adenocarcinoma.

Journal: Bioengineered
Published: 2022
PubMed ID: 35212617
Study type:

combined biological and clinical study
Data availability: GSE158695; GSE101684; GSE112214; Supplemental data for this article can be accessed here.
Code availability: -