| Expression pattern: |
DN |
| Associated gene: |
CEA, CA19-9 |
| Associated microRNA: |
- |
| Biological function: |
Serves as a plasma diagnostic biomarker for CRC; decreased in CRC and precursor lesions; lower plasma levels correlate with higher tumor stage, tumor burden, lymph node metastasis and distal metastasis. |
| Molecular mechanism: |
Not specified; the study evaluated circulating plasma circRNA levels as diagnostic biomarkers. |
| Biological pathway or process: |
metastasis (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
circ-ABCC1 is part of a three-circRNA plasma panel for CRC diagnosis; individual AUC was 0.663 in all samples, and its plasma level was related to tumor growth and progression, precursor lesions, CEA-negative CRC, and CA19-9-negative CRC. |
| Description: |
circ-ABCC1 was significantly decreased in plasma from CRC patients and was included in a three-circRNA diagnostic panel. Lower plasma circ-ABCC1 was associated with higher tumor stage, tumor burden, lymph node metastasis and distant metastasis, and it was also decreased in CRC precursor lesions. |
| Confidence score: |
0.6291 |