circRNA basic information
circBase ID: hsa_circ_000240
Name: hsa_circ_LGALS3BP
Synonym: circ000240 / hsa_circ000240
Host Gene: LGALS3BP
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissue; adjacent normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CDC6, ORC1
Associated microRNA: miR-646, miR-665, miR-526b-3p
Biological function: acts as a ceRNA (miRNA sponge) in CRC
Molecular mechanism: ceRNA mechanism via binding miR-646, miR-665, and miR-526b-3p to regulate downstream genes (including hub genes such as CDC6 and ORC1)
Biological pathway or process:

ceRNA regulation (other); proliferation (other); cell adhesion (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

This study reports that hsa_circ_000240 (from host gene LGALS3BP) is up-regulated in colorectal cancer tissues. It is proposed to function as a ceRNA by binding miR-646, miR-665, and miR-526b-3p to influence downstream target genes (including hub genes such as CDC6 and ORC1) in CRC.
Confidence score:

0.2995
Other information
Title:

The integrative multi-omics approach identifies the novel competing endogenous RNA (ceRNA) network in colorectal cancer.

Journal: Scientific reports
Published: 2023
PubMed ID: 37945594
Study type:

combined biological and clinical study
Data availability: GSE18392; GSE30454; GSE49246; GSE59856; GSE77380; GSE38389; GSE41655; GSE70574; GSE144735
Code availability: -