| Expression pattern: |
UP |
| Associated gene: |
FGFR3 |
| Associated microRNA: |
miR-593-3p |
| Biological function: |
promotes breast cancer malignant progression (cell viability, colony formation, migration, invasion, cell cycle progression) and inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponge: circ_0061825 sponges miR-593-3p to modulate FGFR3 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0061825 (circ_TFF1) is up-regulated in breast cancer and mainly cytoplasmic. It promotes malignant phenotypes and tumor growth by acting as a ceRNA sponge for miR-593-3p, thereby increasing FGFR3 expression. |
| Confidence score: |
0.7801 |