| Expression pattern: |
UP |
| Associated gene: |
PTP4A1, Bcl-2, Bax, Ki-67 |
| Associated microRNA: |
miR-625-5p |
| Biological function: |
Acts as an oncogene; promotes cervical cancer cell proliferation, migration, invasion, angiogenesis and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circ_0000212 functions as a ceRNA/miR-625-5p sponge to upregulate PTP4A1 in cervical cancer. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; EdU Staining; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0000212 represented a candidate helpful marker of cervical cancer patient prognosis and an invaluable target for cervical cancer clinical treatments. |
| Description: |
circ_0000212 is up-regulated in cervical cancer tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, angiogenesis and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0000212 sponges miR-625-5p to positively regulate PTP4A1, forming a circ_0000212/miR-625-5p/PTP4A1 ceRNA axis. |
| Confidence score: |
0.8006 |