| Expression pattern: |
UP |
| Associated gene: |
Zeb1, Zeb1 mRNA, YTHDF3 |
| Associated microRNA: |
- |
| Biological function: |
circ_KIAA1429 promotes HCC cell migration, invasion, metastasis and EMT; knockdown inhibits these phenotypes. |
| Molecular mechanism: |
circ_KIAA1429 maintains Zeb1 expression through an m6A-YTHDF3-Zeb1 mechanism; YTHDF3 enhances Zeb1 mRNA stability in an m6A-dependent manner. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); m6A modification (promotes); mRNA stability (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry); RNA Pull-Down; RIP (RNA Immunoprecipitation); Actinomycin D / DRB Stability Assay |
| Clinical significance: |
circ_KIAA1429 might represent a potential therapeutic target in HCC. |
| Description: |
circ_KIAA1429/hsa_circ_0084922 is derived from KIAA1429 and is upregulated in HCC tissues and cell lines. It promotes HCC migration, invasion, metastasis and EMT, at least partly by maintaining Zeb1 expression through an m6A-YTHDF3-Zeb1 mechanism that enhances Zeb1 mRNA stability. The study suggests circ_KIAA1429 may be a potential therapeutic target in HCC. |
| Confidence score: |
0.8162 |