circRNA basic information
circBase ID: hsa_circ_0000211
Name: hsa_circ_SFMBT2
Synonym: hsa_-circ_000524
Host Gene: SFMBT2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LAC tissues; matched adjacent noncancerous tissues
Cell lines:

A549; H1299; H1650; BEAS-2B; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HIF1A / HIF1-a / HIF-1a
Associated microRNA: miR-622
Biological function: Promotes lung adenocarcinoma cell migration and invasion; knockdown inhibits migration and invasion.
Molecular mechanism: hsa-circ-0000211 functions as a ceRNA/miRNA sponge for miR-622 and upregulates HIF1A/HIF1-a expression, thereby promoting LAC cell migration and invasion.
Biological pathway or process:

migration (promotes); invasion (promotes); metastasis (promotes); HIF-1 signaling (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot
Clinical significance:

hsa-circ-0000211 expression was positively correlated with distant metastasis and may be a potential therapeutic target for LAC.
Description:

hsa-circ-0000211 is up-regulated in lung adenocarcinoma tissues and cell lines. It promotes LAC cell migration and invasion by sponging miR-622 and increasing HIF1A/HIF1-a expression, and its expression is positively associated with distant metastasis, suggesting potential therapeutic relevance.
Confidence score:

0.7759
Other information
Title:

A novel circular RNA, hsa-circ-0000211, promotes lung adenocarcinoma migration and invasion through sponging of hsa-miR-622 and modulating HIF1-alpha expression.

Journal: Biochemical and biophysical research communications
Published: 2020
PubMed ID: 31668923
Study type:

combined biological and clinical study
Data availability: Supplementary data to this article can be found online at https://doi.org/10.1016/j.bbrc.2019.10.134
Code availability: -