| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Independent prognostic biomarker candidate in surgically treated PDAC; also showed ROC biomarker potential for short-term survival. |
| Molecular mechanism: |
Not mechanistically characterized in this study; association based on differential expression profiling, RT-qPCR validation, and survival analysis. |
| Biological pathway or process: |
not specified (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis; ROC Analysis |
| Clinical significance: |
High expression was associated with worse overall survival and circMBOAT2 showed independent prognostic value in multivariate analysis. |
| Description: |
circMBOAT2 was up-regulated in PDAC and its higher expression was linked to poorer survival. The study validated its increased expression by RT-qPCR and identified it as an independent prognostic marker. |
| Confidence score: |
0.5534 |