circRNA basic information
circBase ID: hsa_circ_0007334
Name: hsa_circ_MBOAT2
Synonym: circ_00761_MBOAT2
Host Gene: MBOAT2
Genomic location(hg19): chr2:9083315-9098771:-
Genomic location(hg38): chr2:8943186-8958642:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

frozen tumor tissue; FFPE surgical PDAC specimens; normal pancreas; peritumoral pancreatitis; autoimmune pancreatitis
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Independent prognostic biomarker candidate in surgically treated PDAC; also showed ROC biomarker potential for short-term survival.
Molecular mechanism: Not mechanistically characterized in this study; association based on differential expression profiling, RT-qPCR validation, and survival analysis.
Biological pathway or process:

not specified (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis; ROC Analysis
Clinical significance:

High expression was associated with worse overall survival and circMBOAT2 showed independent prognostic value in multivariate analysis.
Description:

circMBOAT2 was up-regulated in PDAC and its higher expression was linked to poorer survival. The study validated its increased expression by RT-qPCR and identified it as an independent prognostic marker.
Confidence score:

0.5534
Other information
Title:

Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Published: 2024
PubMed ID: 38724419
Study type:

combined bioinformatics and clinical study
Data availability: Supplementary Table 4; Supplementary Table 5; https://doi.org/10.1016/j.pan.2024.04.004
Code availability: -