circRNA basic information
circBase ID: hsa_circ_0084922
Name: hsa_circ_KIAA1429
Synonym: circ_KIAA1429
Host Gene: KIAA1429
Genomic location(hg19): chr8:95547066-95550574:-
Genomic location(hg38): chr8:94534838-94538346:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; matched adjacent tissues; tumor tissues; xenograft tumor tissues; lung metastasis tumors
Cell lines:

Bel-7402; SMMC-7721; Bel-7404; HepG2; Huh-7; L02
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: Zeb1, Zeb1 mRNA, YTHDF3
Associated microRNA: -
Biological function: circ_KIAA1429 promotes HCC cell migration, invasion, metastasis and EMT; knockdown inhibits these phenotypes.
Molecular mechanism: circ_KIAA1429 maintains Zeb1 expression through an m6A-YTHDF3-Zeb1 mechanism; YTHDF3 enhances Zeb1 mRNA stability in an m6A-dependent manner.
Biological pathway or process:

migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); m6A modification (promotes); mRNA stability (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry); RNA Pull-Down; RIP (RNA Immunoprecipitation); Actinomycin D / DRB Stability Assay
Clinical significance:

circ_KIAA1429 might represent a potential therapeutic target in HCC.
Description:

circ_KIAA1429/hsa_circ_0084922 is derived from KIAA1429 and is upregulated in HCC tissues and cell lines. It promotes HCC migration, invasion, metastasis and EMT, at least partly by maintaining Zeb1 expression through an m6A-YTHDF3-Zeb1 mechanism that enhances Zeb1 mRNA stability. The study suggests circ_KIAA1429 may be a potential therapeutic target in HCC.
Confidence score:

0.8162
Other information
Title:

circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m6A-YTHDF3-Zeb1.

Journal: Life sciences
Published: 2020
PubMed ID: 32653519
Study type:

combined biological and clinical study
Data availability: starBase; GEPIA; Kaplan Meier Plotter; circBank; TCGA samples in starBase database; Supplementary Table S1; Supplementary Table S2; https:// doi.org/10.1016/j.lfs.2020.118082
Code availability: -