circRNA basic information
circBase ID: hsa_circ_0001017
Name: -
Synonym: circ_0001017
Host Gene: -
Genomic location(hg19): chr2:61749745-61761038:-
Genomic location(hg38): chr2:61522610-61533903:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Saos-2; U2OS; MG63; HECC; hFOB1.19; HFF-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Ago2
Associated microRNA: miR-145-5p
Biological function: promotes cell proliferation, migration and invasion; decreases apoptosis
Molecular mechanism: sponges miR-145-5p via direct binding and negatively regulates miR-145-5p
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation)
Clinical significance:

-
Description:

hsa_circ_0001017 is up-regulated in osteosarcoma cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration and invasion and inhibits apoptosis in U2OS cells by sponging miR-145-5p and negatively regulating its expression.
Confidence score:

0.627
Other information
Title:

Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p.

Journal: Journal of orthopaedic surgery and research
Published: 2022
PubMed ID: 35346268
Study type:

biological research
Data availability: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -