circRNA basic information
circBase ID: -
Name: hsa_circ_MYH9
Synonym: hsa_circRNA_001226
Host Gene: MYH9
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005701
MONDO name: chlamydia trachomatis infectious disease
Disease details: Chlamydia trachomatis infection
Disease DO ID:
 11263
Disease MeSH ID:
 -
Disease NCIt ID:
 C34463
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HeLa
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Rab11A
Associated microRNA: hsa-miR-637, hsa-miR-3192-5p, hsa-miR-661, hsa-miR-5787, hsa-miR-762
Biological function: Promotes chlamydial infection-associated host interaction and may facilitate pathogen survival in host cells.
Molecular mechanism: ceRNA mechanism via miRNA sponge activity.
Biological pathway or process:

endocytosis (other); PI3K/AKT (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_001226 is upregulated in Chlamydia trachomatis-infected HeLa cells. The authors suggest it may function as a miRNA sponge in a circRNA/miRNA/mRNA regulatory network, potentially affecting Rab11A-related host-pathogen interactions and promoting Chlamydia survival.
Confidence score:

0.2465
Other information
Title:

Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis.

Journal: Pathogens and disease
Published: 2019
PubMed ID: 31665272
Study type:

combined biological and clinical study
Data availability: -
Code availability: -