circRNA basic information
circBase ID: hsa_circ_0007991
Name: hsa_circ_EIF4G3
Synonym: -
Host Gene: EIF4G3
Genomic location(hg19): chr1:21329205-21415706:-
Genomic location(hg38): chr1:21002712-21089213:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissue; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: May be involved in gastric cancer development; proposed as a diagnostic/prognostic marker and therapeutic target (bioinformatics-based).
Molecular mechanism: Bioinformatics prediction of downstream miRNAs/mRNAs and functional enrichment; no validated axis for this circRNA.
Biological pathway or process:

p53 signaling (other); apoptosis (other); signaling pathways regulating pluripotency of stem cells (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Could be novel diagnostic or prognostic markers, as well as therapeutic targets for gastric cancer.
Description:

hsa_circ_0007991 was identified as a differentially expressed circRNA in gastric cancer by integrated analysis of GEO circRNA microarrays. The study suggests it may relate to cancer-associated pathways (e.g., pluripotency of stem cells and p53 signaling) based on enrichment of predicted downstream genes, but no specific validated miRNA/mRNA axis was supported by TCGA intersection for this circRNA.
Confidence score:

0.1768
Other information
Title:

Down-regulated hsa_circ_0067934 facilitated the progression of gastric cancer by sponging hsa-mir-4705 to downgrade the expression of BMPR1B.

Journal: Translational cancer research
Published: 2019
PubMed ID: 35117027
Study type:

bioinformatics study
Data availability: GSE78092; GSE83521; GSE89143; GSE93541; TCGA-STAD
Code availability: -