circRNA basic information
circBase ID: hsa_circ_0006877
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr19:11230767-11231198:+
Genomic location(hg38): chr19:11120091-11120522:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCT116; Lovo; HT29; SW480
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: May play a role in 5-Fu resistance in CRC; proposed as potential predictive biomarker/therapeutic target.
Molecular mechanism: Potential ceRNA mechanism (circRNA-miRNA-mRNA network predicted), but no specific validated axis detailed in text for this circRNA.
Biological pathway or process:

ceRNA regulation (other); drug resistance (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis
Clinical significance:

May represent a potential predictive biomarker and possible therapeutic target of 5-Fu resistance.
Description:

hsa_circ_0006877 is generally up-regulated in 5-Fu-resistant CRC cell lines (except not significantly changed in SW480). It is proposed to be involved in 5-Fu resistance with predicted ceRNA network involvement and suggested as a potential biomarker/therapeutic target for 5-Fu resistance.
Confidence score:

0.2465
Other information
Title:

RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers.

Journal: World journal of gastrointestinal oncology
Published: 2022
PubMed ID: 35321280
Study type:

biological research
Data availability: The datasets used during the current study were available from the corresponding authors on reasonable request.
Code availability: -