| Expression pattern: |
DN |
| Associated gene: |
NLRP3 |
| Associated microRNA: |
miR-223-3p |
| Biological function: |
suppresses gastric cancer cell viability/proliferation and tumor growth; promotes pyroptosis when induced by icariin |
| Molecular mechanism: |
ceRNA mechanism by sponging miR-223-3p to regulate NLRP3 expression |
| Biological pathway or process: |
pyroptosis (promotes); proliferation (inhibits); cell viability (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Western Blot; In Vivo Animal Model |
| Clinical significance: |
downregulation of hsa_circ_0003159 has potential clinical importance in GC and is related to lower disease-free survival and overall survival |
| Description: |
hsa_circ_0003159 is downregulated in gastric cancer and acts as a tumor-suppressive circRNA in this study context. It sponges miR-223-3p to upregulate NLRP3, thereby affecting cell viability and pyroptosis; icariin exerts anti-gastric-cancer effects partly through this axis. |
| Confidence score: |
0.6207 |