circRNA basic information
circBase ID: hsa_circ_0005927
Name: hsa_circ_VDAC3
Synonym: hsa_circRNA_104600
Host Gene: VDAC3
Genomic location(hg19): chr8:42259305-42260979:+
Genomic location(hg38): chr8:42401787-42403461:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; CRC tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Acts as a circulating plasma diagnostic biomarker for CRC; correlated with tumor size.
Molecular mechanism: Not mechanistically tested; plasma levels were positively correlated with intratumoral levels and decreased after tumor resection, suggesting tumor-derived circulating circRNA.
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Upregulated plasma hsa_circ_0005927 had diagnostic value for CRC with AUC 0.784 and was correlated with tumor size.
Description:

hsa_circ_0005927 is upregulated in plasma and CRC tumor tissues of CRC patients. It showed the highest individual AUC among the three validated circRNAs and contributed to a plasma CircPanel proposed for CRC diagnosis, including CEA-negative CRC detection.
Confidence score:

0.63
Other information
Title:

Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer detection.

Journal: American journal of translational research
Published: 2020
PubMed ID: 33312376
Study type:

combined biological and clinical study
Data availability: Table S3; Table S4; Table S5
Code availability: -