| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circRNA ciRS-7 overexpression correlated with advanced disease and poor prognosis in NSCLC patients; down-regulation inhibited A549 cell proliferation and promoted apoptosis. |
| Molecular mechanism: |
not specified; functional inhibition of circRNA ciRS-7 reduced proliferation and increased apoptosis in A549 cells. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cohort Study; Survival Analysis |
| Clinical significance: |
circRNA ciRS-7 high expression was associated with larger tumor size, lymph node metastasis, poor TNM stage, shorter DFS and OS, and independently predicted unfavorable DFS and OS. |
| Description: |
In this study, circRNA ciRS-7 was up-regulated in NSCLC tumor tissues and NSCLC cell lines. High tumor tissue expression correlated with advanced clinicopathological features and poorer DFS/OS, while experimental down-regulation in A549 cells suppressed proliferation and promoted apoptosis, suggesting an oncogenic role and potential clinical prognostic value in NSCLC. |
| Confidence score: |
0.6419 |