circRNA basic information
circBase ID: hsa_circ_0001785
Name: hsa_circ_ELP3
Synonym: circ-ELP3
Host Gene: ELP3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer / TNBC
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; paired adjacent normal tissue
Cell lines:

MDA-MB-231; MDA-MB-468; MCF-7; MCF10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ELP3 mRNA
Associated microRNA: -
Biological function: promotes cell viability, proliferation, colony formation, tumorigenicity, and cell cycle progression in breast cancer cells, particularly TNBC cell lines
Molecular mechanism: circ-ELP3 may exert oncogenic effects by indirectly regulating ELP3 expression; ELP3 mRNA expression is positively correlated with circ-ELP3 expression
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; Cell Cycle Assay; Colony Formation Assay
Clinical significance:

-
Description:

circ-ELP3/hsa-circ-0001785 is upregulated in TNBC tissues and breast cancer cell lines. Functional overexpression experiments show that it promotes breast cancer cell proliferation, viability, colony formation, and cell cycle progression, and it may act partly through indirect regulation of its host gene ELP3.
Confidence score:

0.6996
Other information
Title:

Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer.

Journal: Cell biochemistry and function
Published: 2022
PubMed ID: 35722999
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -