| Expression pattern: |
UP |
| Associated gene: |
ERBB4 |
| Associated microRNA: |
miR-1304 |
| Biological function: |
circ_0074026 promotes glioma cell growth, migration and invasion, inhibits apoptosis, and facilitates oncogenesis and tumor progression. |
| Molecular mechanism: |
circ_0074026 functions as a miR-1304 sponge to positively regulate ERBB4 expression, thereby promoting glioma progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0074026 expression is associated with larger tumor size, higher WHO grade, worse overall survival, worse disease-free survival, and may act as an independent prognostic predictor in glioma. |
| Description: |
circ_0074026 is up-regulated in glioma tissues and cell lines, and high expression predicts unfavorable prognosis. Functionally, circ_0074026 promotes glioma cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it sponges miR-1304 to upregulate ERBB4 expression and thereby facilitates glioma progression. |
| Confidence score: |
0.7126 |