circRNA basic information
circBase ID: hsa_circ_0005654
Name: hsa_circ_PRDM5
Synonym: -
Host Gene: PRDM5
Genomic location(hg19): chr4:121675707-121732604:-
Genomic location(hg38): chr4:120754552-120811449:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

healthy gastric mucosa samples; early gastric cancer mucosae; adjacent nontumor mucosae; chronic gastritis tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: serves as a new and promising diagnostic biomarker for screening early gastric cancer
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

hsa_circ_0005654 may serve as a diagnostic biomarker for screening early gastric cancer; AUCs were 0.927 for early gastric cancer tissues vs. paired normal adjacent mucosae and 0.924 for early gastric cancer vs. healthy controls
Description:

This study found that hsa_circ_0005654 is significantly down-regulated in early gastric cancer mucosae compared with matched adjacent nontumor mucosae and healthy gastric mucosa samples. Its diagnostic performance was evaluated by ROC analysis, with AUCs of 0.927 and 0.924, supporting its potential use as an early diagnostic biomarker for gastric cancer.
Confidence score:

0.5958
Other information
Title:

Identification of hsa_circ_0005654 as a new early biomarker of gastric cancer.

Journal: Cancer biomarkers : section A of Disease markers
Published: 2019
PubMed ID: 31640088
Study type:

clinical study
Data availability: GSE89143; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89143; http://www.circbase.org/cgi-bin/simplesearch.cgi; http://www.circbase.org/cgi-bin/singlerecord.cgi?id=hsa_circ_0005654
Code availability: -