| Expression pattern: |
DN |
| Associated gene: |
FOXP2 |
| Associated microRNA: |
miR-25-3p |
| Biological function: |
Suppresses proliferation, migration, invasion, EMT; promotes apoptosis; inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA that sponges miR-25-3p to de-repress FOXP2, thereby inhibiting NSCLC progression. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; ISH (In Situ Hybridization); Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
Potential biomarker for early diagnosis of NSCLC. |
| Description: |
hsa_circ_0043265 is downregulated in NSCLC tissues/cells and functions as a tumor suppressor. It sponges miR-25-3p to increase FOXP2 expression, thereby inhibiting proliferation, migration/invasion and EMT while promoting apoptosis, and it suppresses xenograft tumor growth. |
| Confidence score: |
0.7979 |