| Expression pattern: |
UP |
| Associated gene: |
PTEN |
| Associated microRNA: |
hsa-miR-142-5p |
| Biological function: |
Acts as a ceRNA in AMI network; proposed to restrain miRNA function to affect PTEN reduction. |
| Molecular mechanism: |
ceRNA mechanism via binding hsa-miR-142-5p to regulate PTEN. |
| Biological pathway or process: |
ceRNA regulation (other); autophagy (other); apoptosis (other); PI3K/AKT (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis; Transfection |
| Clinical significance: |
- |
| Description: |
hsa_circ_0031017 is up-regulated in AMI and was validated by qRT-PCR. It is proposed to act in a ceRNA axis by binding hsa-miR-142-5p to affect PTEN expression, linking the circRNA network to AMI-related processes such as autophagy/apoptosis. |
| Confidence score: |
0.5922 |