| Expression pattern: |
UP |
| Associated gene: |
p53, cyclinD1, CDK6, MMP-2, MMP-9, TIMP-1, JAK1, STAT3, MEK, ERK |
| Associated microRNA: |
miR-99a |
| Biological function: |
Promotes renal carcinoma cell viability, colony formation and migration. |
| Molecular mechanism: |
circFNDC3B downregulates miR-99a and promotes JAK1/STAT3 and MEK/ERK signaling pathways. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); JAK/STAT (promotes); ERK (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot |
| Clinical significance: |
This article may afford a new thought for the clinical treatment of RC. |
| Description: |
circFNDC3B is up-regulated in renal carcinoma tissues and promotes malignant phenotypes in ACHN and CAKI-1 cells, including viability, colony formation and migration. Mechanistically, circFNDC3B negatively regulates miR-99a and enhances JAK1/STAT3 and MEK/ERK signaling pathway activity. |
| Confidence score: |
0.6261 |