circRNA basic information
circBase ID: hsa_circ_0024731
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr11:123489400-123489932:+
Genomic location(hg38): chr11:123618692-123619224:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; normal tissue; para-carcinoma normal tissue samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: mRNAs in ceRNA network
Associated microRNA: -
Biological function: Identified as a diagnostic biomarker in NSCLC; functional analysis associated the five circRNA biomarkers with tumor progression and miRNA regulation, but no individual functional experiment was performed for this circRNA.
Molecular mechanism: Bioinformatically constructed ceRNA network; experimental validation of the regulatory mechanism was not performed.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other); immune regulation (other)
Detected method:
Q
M
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic biomarker for NSCLC with AUC > 0.85; included in a nomogram model for patients with NSCLC.
Description:

hsa_circ_0024731 was significantly upregulated in NSCLC tumor tissues and was identified as one of five potential diagnostic circRNA biomarkers. The study suggested its involvement in a predicted ceRNA network and tumor-related biological processes, but no individual functional or mechanistic experiment was reported for this circRNA.
Confidence score:

0.459
Other information
Title:

Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer.

Journal: Cell biochemistry and biophysics
Published: 2025
PubMed ID: 40251360
Study type:

combined bioinformatics, biological and clinical study
Data availability: GSE101586; GSE112214; GSE158695; GSE101684; GSE30219
Code availability: -