circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: -
Host Gene: ITCH
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

DU 145; 22RV1; VCaP; PC-3; RWPE-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-197
Biological function: Inhibits cell proliferation and promotes apoptosis in prostate cancer cells.
Molecular mechanism: circ-ITCH targets (downregulates) miR-197; miR-197 overexpression attenuates circ-ITCH effects on proliferation/apoptosis.
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

In prostate cancer cell lines, circ-ITCH is down-regulated versus normal prostate epithelial cells. Forced circ-ITCH expression suppresses proliferation and increases apoptosis in PC-3 cells, mainly by targeting and downregulating miR-197, as supported by rescue experiments.
Confidence score:

0.5554
Other information
Title:

Upregulation of Circular RNA Itchy E3 Ubiquitin Protein Ligase Inhibits Cell Proliferation and Promotes Cell Apoptosis Through Targeting MiR-197 in Prostate Cancer.

Journal: Technology in cancer research & treatment
Published: 2019
PubMed ID: 31694481
Study type:

biological research
Data availability: -
Code availability: -