circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1
Synonym: CDR1as / CircRNA CDR1as
Host Gene: CDR1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome; extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent normal tissues; plasma; plasma exosome samples
Cell lines:

GES-1; MGC-803; MKN-45; AGS; BGC-823
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: HSPE1, HSPB1, KHDRBS1, LSM3, EEF1G, Vimentin
Associated microRNA: -
Biological function: CDR1as is associated with GC progression, tumor size, neural invasion, lymphatic metastasis, diagnosis and prognosis; CDR1as-regulated proteins participate in growth, adhesion, miRNA signaling networks, glycine, serine and threonine metabolism.
Molecular mechanism: CDR1as regulates downstream proteins and signaling pathways identified by quantitative proteomics and bioinformatic analysis, including cancer-related miRNA signaling networks, glycine, serine and threonine metabolism, and HSPE1 as a possible key protein.
Biological pathway or process:

proliferation (other); migration (other); invasion (other); metastasis (inhibits); ceRNA regulation (other); other pathway/process (other); immune regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis; Bioinformatics Analysis; Transfection
Clinical significance:

Tissue- and plasma-derived CDR1as have diagnostic potential for GC; tissue-derived CDR1as is an independent predictor for overall survival and a potential prognostic biomarker.
Description:

This study found that CDR1as is dysregulated in gastric cancer: it is downregulated in GC tissues and cell lines but upregulated in plasma and plasma exosomes. Tissue-derived CDR1as showed diagnostic value and independently predicted overall survival, with lower tissue expression associated with shorter survival. Proteomic and bioinformatic analyses suggested that CDR1as regulates GC-related biological processes through downstream proteins and pathways, including miRNA signaling networks, glycine/serine/threonine metabolism, and HSPE1.
Confidence score:

0.6815
Other information
Title:

CircRNA CDR1as: a novel diagnostic and prognostic biomarker for gastric cancer.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Published: 2023
PubMed ID: 37128800
Study type:

combined biological and clinical study
Data availability: The dataset used and/or analyzed during current study are available from the corresponding author on reasonable request.
Code availability: -