| Expression pattern: |
DN |
| Associated gene: |
ICAM-1 |
| Associated microRNA: |
miR-6852-3p |
| Biological function: |
Enhances susceptibility of HCC cells to NK cell-mediated cytotoxicity and may act as a tumor suppressor in HCC progression/metastasis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-6852-3p, thereby regulating ICAM-1 expression and NK cell cytotoxicity toward HCC cells. |
| Biological pathway or process: |
immune regulation (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Western Blot; Flow Cytometry（Non-apoptosis/cycle） |
| Clinical significance: |
Low hsa_circ_0007456 expression is associated with poorer progression of HCC and it is proposed as a promising biomarker; it was reported as correlated with prognosis of HCC. |
| Description: |
In HCC, hsa_circ_0007456 is down-regulated and increases tumor-cell susceptibility to NK cell-mediated killing. Mechanistically, it sponges miR-6852-3p to upregulate ICAM-1, and the miR-6852-3p/ICAM-1 axis is required for the NK-cytotoxicity phenotype. |
| Confidence score: |
0.6324 |