| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-29a-3p |
| Biological function: |
promotes prostate cancer cell survival, proliferation, migration, invasion and metastasis |
| Molecular mechanism: |
circ_0044516 acts as a miRNA sponge and interacts with miR-29a-3p, downregulating miR-29a-3p expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Bioinformatics Analysis |
| Clinical significance: |
potential biomarker; higher levels in high metastatic prostate cancer blood exosomes |
| Description: |
hsa_circ_0044516/circ_0044516 is upregulated in prostate cancer exosomes, tissues and cell lines. It promotes prostate cancer cell proliferation and metastatic behaviors, at least partly by acting as a sponge for miR-29a-3p, and may serve as a potential biomarker. |
| Confidence score: |
0.7404 |