| Expression pattern: |
UP |
| Associated gene: |
SOX6, ERK, Cyclin D1, Bcl-2, Bax |
| Associated microRNA: |
miR-122 |
| Biological function: |
Circ_PTN acts as an oncogene in glioma cells; its knockdown inhibits cell proliferation, induces cell cycle arrest, and promotes apoptosis. |
| Molecular mechanism: |
Circ_PTN sponges miR-122 to upregulate SOX6 and activate the MAPK/ERK pathway, with downstream changes in Cyclin D1, Bcl-2 and Bax. |
| Biological pathway or process: |
MAPK (promotes); ERK (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
- |
| Description: |
Circ_PTN is up-regulated in human glioma cell lines and functions as an oncogenic circRNA. It promotes glioma cell proliferation and cell-cycle progression while suppressing apoptosis by sponging miR-122, thereby increasing SOX6 expression and activating MAPK/ERK-related signaling. |
| Confidence score: |
0.5607 |