circRNA basic information
circBase ID: hsa_circ_0026344
Name: -
Synonym: circ_0026344
Host Gene: -
Genomic location(hg19): chr12:52314542-52317145:+
Genomic location(hg38): chr12:51920758-51923361:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SW480; Caco-2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: Wnt3a, b-catenin
Associated microRNA: miR-183
Biological function: circ_0026344 restrains CRC cell metastasis, migration, invasion and EMT; silencing circ_0026344 promotes migration, invasion and EMT.
Molecular mechanism: circ_0026344 negatively regulates miR-183 and represses miR-183-dependent Wnt/b-catenin signalling.
Biological pathway or process:

Wnt/beta-catenin (inhibits); EMT (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Transwell Assay; Western Blot
Clinical significance:

-
Description:

In human CRC cell lines, CCL20 and CXCL8 co-stimulation down-regulated circ_0026344. Functional experiments showed that circ_0026344 suppresses CRC cell migration, invasion, metastasis-related EMT, and Wnt/b-catenin signaling, at least partly through negative regulation of miR-183.
Confidence score:

0.3957
Other information
Title:

Circ_0026344 restrains metastasis of human colorectal cancer cells via miR-183.

Journal: Artificial cells, nanomedicine, and biotechnology
Published: 2019
PubMed ID: 31608699
Study type:

biological research
Data availability: -
Code availability: -