| Expression pattern: |
UP |
| Associated gene: |
RTKN2 |
| Associated microRNA: |
miR-1299 |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion, motility and tumour formation, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0088046 functions as a ceRNA by sponging miR-1299, thereby regulating RTKN2 expression in HCC cells. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0088046 is proposed as a promising candidate target for the treatment of HCC. |
| Description: |
circ_0088046 is up-regulated in HCC tissues and cells. It promotes HCC cell proliferation, migration, invasion and in vivo tumour growth while suppressing apoptosis. Mechanistically, circ_0088046 acts as a ceRNA sponge for miR-1299 to regulate RTKN2, making it a potential therapeutic target for HCC. |
| Confidence score: |
0.8298 |