circRNA basic information
circBase ID: hsa_circ_0000396
Name: hsa_circ_SLC38A1
Synonym: -
Host Gene: SLC38A1
Genomic location(hg19): chr12:46622935-46637097:-
Genomic location(hg38): chr12:46229152-46243314:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008383
MONDO name: rheumatoid arthritis
Disease details: rheumatoid arthritis / RA
Disease DO ID:
 7148
Disease MeSH ID:
 D001172
Disease NCIt ID:
 C2884
Disease ICD11 ID:
 576319925
Disease OMIM ID:
 180300
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells / PBMCs; whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for rheumatoid arthritis based on downregulated expression in RA PBMCs and ROC curve analysis.
Molecular mechanism: Not determined; the study reported differential expression and diagnostic value, while noting that whether and how candidate circRNAs regulate RA pathogenesis remains to be clarified.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0000396 showed diagnostic value for RA, with an AUC of 0.809, and may have potential as a diagnostic biomarker in RA patients.
Description:

hsa_circ_0000396 was significantly downregulated in PBMCs from RA patients compared with healthy controls, as shown by RNA-seq and validated by qRT-PCR. ROC analysis indicated diagnostic value for RA, and the authors highlighted it as a potential diagnostic biomarker.
Confidence score:

0.5047
Other information
Title:

Aberrant dysregulated circular RNAs in the peripheral blood mononuclear cells of patients with rheumatoid arthritis revealed by RNA sequencing: novel diagnostic markers for RA.

Journal: Scandinavian journal of clinical and laboratory investigation
Published: 2019
PubMed ID: 31596149
Study type:

combined bioinformatics and clinical study
Data availability: -
Code availability: -