circRNA basic information
circBase ID: hsa_circ_0000135
Name: hsa_circ_MT1X
Synonym: circ_0000135
Host Gene: MT1X
Genomic location(hg19): chr1:155182175-155202636:+
Genomic location(hg38): chr1:155212384-155232845:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissue; adjacent tissue; matched healthy tissue; paracancerous tissue; tumor tissues
Cell lines:

HeLa 229; MS751; SiHa; HcerEpic
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PDZK1
Associated microRNA: miR-140-3p
Biological function: circ_0000135 promotes cervical cancer cell viability, cell cycle progression, migration, invasion and tumor growth; silencing circ_0000135 inhibits cervical cancer progression.
Molecular mechanism: circ_0000135 functions as a ceRNA by sponging miR-140-3p, thereby regulating PDZK1 expression in cervical cancer.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Cell Cycle Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model
Clinical significance:

High circ_0000135 expression was significantly correlated with FIGO stage, tumor differentiation, and lymph node metastasis in cervical cancer.
Description:

circ_0000135 is up-regulated in cervical cancer tissues and cell lines and is associated with advanced clinicopathological features. The study supports a circ_0000135/miR-140-3p/PDZK1 ceRNA mechanism in which circ_0000135 promotes proliferation, cell cycle progression, migration, invasion and tumor growth, while silencing circ_0000135 suppresses cervical cancer progression.
Confidence score:

0.7657
Other information
Title:

Roles of circ_0000135/miR-140-3p/PDZK1 network in cervical cancer.

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Published: 2022
PubMed ID: 35066758
Study type:

combined biological and clinical study
Data availability: Supplementary material available at https:// doi. org/ 10. 1007/ s12094-021-02751-1
Code availability: -