| Expression pattern: |
UP |
| Associated gene: |
EGFR |
| Associated microRNA: |
miR-769-5p |
| Biological function: |
promotes NSCLC cell proliferation, migration and cell cycle progression; inhibits apoptosis; promotes NSCLC progression |
| Molecular mechanism: |
circ_0001955 acts as a ceRNA by adsorbing miR-769-5p, thereby upregulating EGFR expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); cell cycle (promotes); ceRNA regulation (promotes); EGFR (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; BrdU; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot |
| Clinical significance: |
high circ_0001955 expression was associated with advanced TNM stage, lymph node metastasis, unfavorable pathological characteristics, and worse prognosis in NSCLC patients |
| Description: |
circ_0001955 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage and lymph node metastasis. Functionally, circ_0001955 promotes proliferation, migration and cell cycle progression while inhibiting apoptosis in NSCLC cells. Mechanistically, cytoplasmic circ_0001955 acts as a ceRNA that sponges miR-769-5p and indirectly upregulates EGFR expression to facilitate NSCLC progression. |
| Confidence score: |
0.73 |