| Expression pattern: |
DN |
| Associated gene: |
Foxo3, E-cadherin, N-cadherin, vimentin |
| Associated microRNA: |
5 miRNAs potentially targeting Foxo3 |
| Biological function: |
CircFoxo3 inhibited prostate cancer cell survival, migration, invasion, progression and chemoresistance to docetaxel, promoted docetaxel-induced apoptosis and enhanced chemosensitivity in tumor-bearing mice; silencing circFoxo3 promoted prostate cancer cell survival, migration, invasion, EMT and chemoresistance. |
| Molecular mechanism: |
CircFoxo3 enhanced Foxo3 protein expression by sponging miRNAs shared with linear Foxo3 RNA, thereby repressing EMT; it did not significantly interact with MDM2 or repress MDM2-induced Foxo3 ubiquitination in prostate cancer cells. |
| Biological pathway or process: |
apoptosis (promotes); migration (inhibits); invasion (inhibits); EMT (inhibits); chemoresistance (inhibits); drug resistance (inhibits); ceRNA regulation (other); proliferation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; IHC (Immunohistochemistry); IF (Immunofluorescence); RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Transfection; Annexin V/PI Flow Cytometry; Transwell Assay; TUNEL; In Vivo Animal Model; Western Blot |
| Clinical significance: |
Decreased circFoxo3 may be used as a diagnostic biomarker of prostate cancer and targeting circFoxo3/Foxo3/EMT may provide potential prognostic and therapeutic approaches. |
| Description: |
circFoxo3 is down-regulated in high-grade prostate cancer tissues and more invasive prostate cancer cell lines. Functionally, circFoxo3 suppresses prostate cancer cell survival, migration, invasion, EMT and docetaxel chemoresistance, while promoting apoptosis and chemosensitivity in xenograft-bearing mice. Mechanistically, circFoxo3 appears to sponge miRNAs targeting Foxo3 to enhance Foxo3 protein translation and repress EMT. |
| Confidence score: |
0.8322 |