| Expression pattern: |
UP |
| Associated gene: |
MAT2A |
| Associated microRNA: |
miR-101-5p |
| Biological function: |
promotes proliferation and invasion; promotes tumor growth |
| Molecular mechanism: |
ceRNA sponging miR-101-5p to upregulate MAT2A |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
up-regulated and associated with advanced clinical features; high elevated levels correlated with advanced FIGO stage and lymph-node metastasis |
| Description: |
hsa_circ_0007364 is up-regulated in cervical cancer and is associated with advanced clinical features (FIGO stage and lymph-node metastasis). Functionally, it promotes cervical cancer cell proliferation and invasion and enhances xenograft tumor growth, mainly by sponging miR-101-5p to increase MAT2A expression (miR-101-5p/MAT2A axis). |
| Confidence score: |
0.8432 |