| Expression pattern: |
DN |
| Associated gene: |
BAP1 |
| Associated microRNA: |
miR-7974 |
| Biological function: |
inhibits proliferation, migration and invasion; suppresses tumor growth and bone metastasis |
| Molecular mechanism: |
ceRNA mechanism: Circ_0007552 sponges miR-7974 to upregulate BAP1 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
low Circ_0007552 expression correlated with clinicopathological features and unfavorable prognosis; lower Circ_0007552 expression associated with reduced survival durations |
| Description: |
Circ_0007552 (Circ_RILPL1) is down-regulated in LUAD tissues/cells and functions as a tumor suppressor. It mainly acts via a ceRNA mechanism by sponging miR-7974, thereby relieving repression of BAP1 and inhibiting LUAD proliferation, migration, invasion, tumor growth and bone metastasis; low Circ_0007552 is associated with worse patient survival. |
| Confidence score: |
0.84 |