circRNA basic information
circBase ID: hsa_circ_0032131
Name: hsa_circ_PRKCH
Synonym: hsa_circ_0032131_CBC1
Host Gene: PRKCH
Genomic location(hg19): chr14:61995792-61997313:+
Genomic location(hg38): chr14:61529074-61530595:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005178
MONDO name: osteoarthritis
Disease details: Osteoarthritis / OA
Disease DO ID:
 8398
Disease MeSH ID:
 D010003
Disease NCIt ID:
 C3293
Disease ICD11 ID:
 558562409
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood; chondrocytes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PRKCH
Associated microRNA: hsa-miR-7108-5p, hsa-miR-622, hsa-miR-4655-3p, hsa-miR-6755-5p, hsa-miR-4747-3p, hsa-miR-525-3p, hsa-miR-1182, hsa-miR-505-5p, hsa-miR-6811-5p, hsa-miR-223-3p, hsa-miR-432-5p, miR-16-5p
Biological function: Potential diagnostic biomarker for osteoarthritis; elevated in peripheral blood of OA patients and able to distinguish OA patients from healthy controls.
Molecular mechanism: Predicted targeting miRNAs by miRanda and possible relationship with PRKCH, but functional mechanism remains to be further explored.
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0032131_CBC1 showed diagnostic value for OA with ROC AUC 0.8455, p < 0.01; at 9.365CT cutoff, sensitivity was 0.90 and specificity was 0.65.
Description:

hsa_circ_0032131_CBC1 is up-regulated in the peripheral blood of osteoarthritis patients and was validated by qRT-PCR, consistent with previous microarray findings in chondrocytes. It showed potential diagnostic utility for OA with an AUC of 0.8455, while its predicted miRNA interactions and relationship with PRKCH remain exploratory.
Confidence score:

0.5047
Other information
Title:

Preliminary Exploration of hsa_circ_0032131 Levels in Peripheral Blood as a Potential Diagnostic Biomarker of Osteoarthritis.

Journal: Genetic testing and molecular biomarkers
Published: 2019
PubMed ID: 31526191
Study type:

combined clinical and bioinformatics study
Data availability: -
Code availability: -