circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circRNA_086376
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: EPHA3
Associated microRNA: miR-7
Biological function: May regulate the pulmonary metastasis of CRC.
Molecular mechanism: Predicted miRNA sponge interaction with miR-7; downstream target genes predicted include EPHA3.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; RNase R Treatment; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circRNA_086376 was down-regulated in CRC tissues from patients with lung metastasis versus non-metastatic CRC tissues. It was bioinformatically predicted to bind miR-7 and participate in a metastasis-related regulatory network (e.g., involving EPHA3/PRKCB and NF-kappaB or Wnt signaling), but the interaction was not experimentally validated.
Confidence score:

0.4685
Other information
Title:

Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis.

Journal: International journal of molecular medicine
Published: 2017
PubMed ID: 29039473
Study type:

combined biological and clinical study
Data availability: -
Code availability: -