| Expression pattern: |
UP |
| Associated gene: |
CTCF |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation; promotes migration; promotes invasion; promotes tumor growth |
| Molecular mechanism: |
CTCF acts as an upstream transcription factor regulating circMBOAT2 expression; circMBOAT2 interacts with CTCF (RIP-confirmed); norepinephrine/chronic stress upregulates CTCF and circMBOAT2, enhancing NSCLC progression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; divergent primers PCR; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
circMBOAT2 may serve as a potential biomarker and therapeutic target for NSCLC as well as the treatment of comorbid depression in NSCLC patients. |
| Description: |
circMBOAT2 is up-regulated in NSCLC cells and tumor tissues and functions as an oncogenic circRNA that promotes proliferation, migration, invasion, and in vivo tumor growth, particularly under chronic stress/NE conditions. The study supports an upstream regulatory relationship where stress-induced CTCF increases circMBOAT2 expression, and ASO-mediated silencing of circMBOAT2 suppresses tumor growth. |
| Confidence score: |
0.7654 |