circRNA basic information
circBase ID: hsa_circ_0032131
Name: hsa_circ_PRKCH
Synonym: hsa_circ_0032131_CBC1
Host Gene: PRKCH
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005178
MONDO name: osteoarthritis
Disease details: Osteoarthritis / OA
Disease DO ID:
 8398
Disease MeSH ID:
 D010003
Disease NCIt ID:
 C3293
Disease ICD11 ID:
 558562409
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cartilage specimens; articular cartilage samples; chondrocyte samples of knee joint
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-1182, miR-622
Biological function: hsa_circRNA_0032131 likely participates in the initiation and progression of osteoarthritis and has potential as a diagnostic marker.
Molecular mechanism: Predicted circRNA-miRNA interaction network; possible miRNA sponge or ceRNA-like post-transcriptional regulation.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa_circRNA_0032131 has potential as a diagnostic marker for osteoarthritis.
Description:

hsa_circRNA_0032131 was up-regulated in osteoarthritis chondrocytes and its expression change was consistent between microarray and qRT-PCR validation. The study proposed that it may participate in OA initiation and progression and may serve as a diagnostic biomarker, potentially through predicted circRNA-miRNA sponge interactions.
Confidence score:

0.4032
Other information
Title:

Screening for Differentially Expressed Circular RNAs in the Cartilage of Osteoarthritis Patients for Their Diagnostic Value.

Journal: Genetic testing and molecular biomarkers
Published: 2019
PubMed ID: 31502887
Study type:

combined biological and clinical study
Data availability: The raw data and analytical methods used in this study are available from the authors according to reasonable requirements.
Code availability: -