| Expression pattern: |
DN |
| Associated gene: |
c-MYB |
| Associated microRNA: |
miR-15a-5p |
| Biological function: |
Potential tumor suppressor and diagnostic biomarker in AML. |
| Molecular mechanism: |
Network association with c-MYB and miR-15a-5p; c-MYB positively correlates with circ-HIPK3 expression. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ-HIPK3 shows diagnostic value for distinguishing AML patients from healthy controls (AUC 0.762) and its expression change is associated with RBC count. |
| Description: |
circ-HIPK3 is significantly down-regulated in AML patient BM/PB white blood cells and shows good diagnostic performance (AUC 0.762). It positively correlates with c-MYB within the proposed miR-15a-5p/c-MYB/circ-HIPK3 network, and circ-HIPK3 expression change is associated with RBC count. |
| Confidence score: |
0.559 |