| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
inhibits OSCC cell growth, induces apoptosis, suppresses migration and invasion; mediates the antitumor effect of fucoidan |
| Molecular mechanism: |
fucoidan regulates circFLNA expression and circFLNA in turn affects OSCC cell functions; the study proposes a circFLNA-mediated antitumor mechanism but does not define a specific miRNA axis |
| Biological pathway or process: |
cell cycle (promotes); apoptosis (promotes); migration (inhibits); invasion (inhibits); proliferation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot |
| Clinical significance: |
circFLNA is decreased in OSCC tissues and cells; targeting circFLNA may be relevant for fucoidan-based OSCC treatment |
| Description: |
This study found that circFLNA is downregulated in OSCC tissues and cell lines. Fucoidan upregulated circFLNA, and both fucoidan and circFLNA suppressed OSCC cell proliferation, promoted apoptosis, and inhibited migration and invasion, indicating a circFLNA-mediated antitumor effect. |
| Confidence score: |
0.5442 |