| Expression pattern: |
UP |
| Associated gene: |
ELF3 / E74-like ETS transcription factor 3 |
| Associated microRNA: |
miR-4288 |
| Biological function: |
circHIPK3 promotes NPC cell proliferation, migration, invasion, tumor growth, and metastasis; circHIPK3 knockdown inhibits malignant behaviors in vitro and in vivo. |
| Molecular mechanism: |
circHIPK3 acts as a competing endogenous RNA that sponges miR-4288, thereby protecting ELF3 from miR-4288-mediated silencing and enhancing ELF3 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circHIPK3 expression levels could act as a prognostic marker in NPC patients; higher circHIPK3 expression is associated with lower OS and DMFS rates and with clinical stage and distant metastasis. |
| Description: |
circHIPK3 is up-regulated in nasopharyngeal carcinoma tissues and cell lines, and high expression predicts worse OS and DMFS. Functionally, circHIPK3 promotes NPC proliferation, migration, invasion, tumor growth, and metastasis. Mechanistically, it acts as a ceRNA for miR-4288 to relieve miR-4288-mediated inhibition of ELF3. |
| Confidence score: |
0.7369 |