| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1231, miR-1256 |
| Biological function: |
circ-DCAF6 acts as an oncogene in gastric cancer cells, promoting proliferation, colony formation, migration and invasion, and inhibiting apoptosis. |
| Molecular mechanism: |
circ-DCAF6 functions as a miRNA sponge and upstream negative regulator of miR-1231 and miR-1256 in gastric cancer. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis; Cohort Study |
| Clinical significance: |
High circ-DCAF6 expression was correlated with depth of invasion, lymph node invasion, TNM stage, and worse overall survival; high circ-DCAF6 expression was an independent risk factor affecting GC patient overall survival. |
| Description: |
circ-DCAF6 is up-regulated in gastric cancer tissues and cell lines and its high expression predicts adverse prognosis. Functionally, circ-DCAF6 promotes gastric cancer cell proliferation, colony formation, migration and invasion while inhibiting apoptosis. Mechanistically, circ-DCAF6 acts as a miRNA sponge and upstream negative regulator of miR-1231 and miR-1256. |
| Confidence score: |
0.7365 |