| Expression pattern: |
UP |
| Associated gene: |
CDC42 |
| Associated microRNA: |
miR-520h |
| Biological function: |
circ_SKA3 promotes gastric cancer cell proliferation, cell cycle progression, colony formation, migration, invasion and in vivo tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_SKA3 acts as a post-transcriptional regulator of CDC42 by directly binding miR-520h, functioning through the miR-520h/CDC42 axis. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
Targeting circ_SKA3 might be a new anti-cancer strategy for gastric cancer. |
| Description: |
circ_SKA3 is overexpressed in gastric cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, cell cycle progression, colony formation, migration, invasion and xenograft tumor growth while suppressing apoptosis, at least partly by directly binding miR-520h and relieving repression of CDC42. |
| Confidence score: |
0.8071 |