| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
cZFP609 is potentially involved in the pathogenesis of corneal neovascularization and may act as a proangiogenic factor. |
| Molecular mechanism: |
Potential involvement in corneal neovascularization; the specific molecular mechanism for cZFP609 was not experimentally defined in this study. |
| Biological pathway or process: |
angiogenesis (promotes); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
The human ortholog of cZFP609 was significantly increased in vascularized human corneas and may serve as a promising target for treatment of corneal neovascularization. |
| Description: |
cZFP609 was the most upregulated circRNA in the mouse corneal neovascularization model, and its human ortholog was significantly increased in vascularized human corneas. The authors suggest that cZFP609 may contribute to corneal neovascularization and could be a therapeutic target, although its specific molecular mechanism was not experimentally defined. |
| Confidence score: |
0.5922 |