circRNA basic information
circBase ID: hsa_circ_0006646
Name: hsa_circ_PTK2
Synonym: circ_0006646
Host Gene: PTK2
Genomic location(hg19): chr8:141889569-141900868:-
Genomic location(hg38): chr8:140879470-140890769:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005178
MONDO name: osteoarthritis
Disease details: Osteoarthritis / OA
Disease DO ID:
 8398
Disease MeSH ID:
 D010003
Disease NCIt ID:
 C3293
Disease ICD11 ID:
 558562409
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

articular cartilage tissues / OA cartilage tissues / normal cartilage tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF2BP2, CDH11
Associated microRNA: -
Biological function: promotes chondrocyte apoptosis, inflammation, and ECM degradation; inhibits proliferation in IL-1beta-treated chondrocytes
Molecular mechanism: circ_0006646 binds the RBP IGF2BP2 and enhances IGF2BP2-dependent stabilization/upregulation of CDH11 mRNA
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); inflammation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Western Blot; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; ELISA
Clinical significance:

circ_0006646 was elevated in OA patient tissues; no correlation with disease severity
Description:

circ_0006646 is up-regulated in OA cartilage and in IL-1beta-stimulated human chondrocytes. Functionally, circ_0006646 promotes IL-1beta-induced chondrocyte injury (reduced proliferation, increased apoptosis/inflammation and ECM degradation) by binding IGF2BP2 and enhancing IGF2BP2-dependent stabilization and upregulation of CDH11.
Confidence score:

0.7009
Other information
Title:

Circ_0006646 Promotes the Progression of Osteoarthritis via Upregulating CDH11 Expression in an IGF2BP2-Dependent Manner.

Journal: The Kaohsiung journal of medical sciences
Published: 2025
PubMed ID: 40387410
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -