| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Downregulation of circ_0026344 is associated with tumour malignant behavior, including tumour size, lymph node metastasis, TNM stage, invasive depth, and poorer overall survival in gastric cancer. |
| Molecular mechanism: |
No molecular mechanism was experimentally defined in gastric cancer; the study focused on expression and clinical prognostic significance. |
| Biological pathway or process: |
metastasis (inhibits); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
Low circ_0026344 expression is associated with tumour malignant behaviors and poor prognosis, and circ_0026344 expression is an independent predictor for overall survival in gastric cancer patients. |
| Description: |
This study found that circ_0026344 is downregulated in gastric cancer tissues and gastric cancer cell lines. Low circ_0026344 expression is associated with malignant clinicopathologic features and worse overall survival, supporting its potential value as a prognostic biomarker in gastric cancer. |
| Confidence score: |
0.6089 |