| Expression pattern: |
DN |
| Associated gene: |
P53, SLC7A11 |
| Associated microRNA: |
miR-1228 |
| Biological function: |
inhibits cell proliferation, migration, and invasion; promotes ferroptosis; suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0015278 sponges miR-1228 to increase P53 expression and downregulate SLC7A11, enhancing ferroptosis |
| Biological pathway or process: |
ferroptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_0015278 is down-regulated in LUAD tissues/cell lines and acts as a tumor suppressor. It promotes ferroptosis and inhibits proliferation/migration/invasion by sponging miR-1228 to upregulate P53 and suppress SLC7A11, reducing LUAD growth in a xenograft model. |
| Confidence score: |
0.7401 |