| Expression pattern: |
DN |
| Associated gene: |
NFKBIA |
| Associated microRNA: |
hsa-mir-543, hsamir-135a/135b-5p, hsa-mir-640, hsa-mir-499a-3p |
| Biological function: |
Novel predictive diagnostic biomarker for distinguishing SRNS from SSNS; may participate in the pathogenesis of nephrotic syndrome. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA regulatory network; predicted targeting of miRNAs including hsa-mir-499a-3p, with downstream NFKBIA/NF-kappaB inflammatory signaling implications. |
| Biological pathway or process: |
ceRNA regulation (other); Wnt/beta-catenin (other); NF-kappaB (inhibits); inflammation (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Diagnostic biomarker for discriminating SRNS from SSNS; AUC = 0.90. |
| Description: |
hsa_circRNA_101015 is down-regulated in PBMCs of children with SRNS compared with SSNS and was validated by qRT-PCR. It shows strong diagnostic performance for distinguishing SRNS from SSNS and is proposed to participate in NS pathogenesis through a predicted circRNA-miRNA-mRNA network involving miRNAs such as hsa-mir-499a-3p and inflammatory/NF-kappaB-related targets. |
| Confidence score: |
0.5963 |