circRNA basic information
circBase ID: hsa_circ_0049657
Name: hsa_circ_NFIX
Synonym: -
Host Gene: NFIX
Genomic location(hg19): chr19:13183860-13186485:+
Genomic location(hg38): chr19:13073046-13075671:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: Non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung cancer tissue; adjacent standard tissue
Cell lines:

A549; SK-MES-1; H1299; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Inhibits proliferation and migration/invasion; promotes apoptosis of NSCLC cells (upon overexpression).
Molecular mechanism: Not defined; mechanism requires further investigation.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry
Clinical significance:

Potential biomarker for NSCLC.
Description:

hsa_circ_0049657 (derived from NFIX) is down-regulated in NSCLC tissues and cell lines. Its overexpression suppresses NSCLC cell proliferation and migration/invasion and increases apoptosis, suggesting a tumor-suppressive role and potential biomarker value, although the molecular mechanism was not determined.
Confidence score:

0.5358
Other information
Title:

Circular RNA hsa_circ_0049657 as a Potential Biomarker in Non-Small Cell Lung Cancer.

Journal: International journal of molecular sciences
Published: 2023
PubMed ID: 37686043
Study type:

combined biological and clinical study
Data availability: TCGA-LUAD; TCGA-LUSC; GDC databases of TCGA
Code availability: -