| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-4725-3p, hsa-miR-671-5p |
| Biological function: |
Predicted to probably participate in pathways regulating SGA pathogenesis; specific biological function was not experimentally validated. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA ceRNA interaction involving hsa-miR-4725-3p and hsa-miR-671-5p. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Differential expression in umbilical cord and maternal blood plasma may provide a basis for predicting fetal plasma content in maternal plasma. |
| Description: |
hsa_circ_0001360 was down-regulated in SGA umbilical cord and maternal plasma and was validated by RT-PCR. The study predicted that it may participate in SGA-related ceRNA regulation through hsa-miR-4725-3p and hsa-miR-671-5p, although specific downstream functions were not experimentally defined. |
| Confidence score: |
0.6193 |